Src Substrate Surprise
نویسندگان
چکیده
منابع مشابه
to a v-src Substrate and Is Located in
in cell-substratum contact sites. homologous to a v-src substrate and is located overexpressed in human carcinomas, is The product of the EMS1 gene, amplified and
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Some years ago, we employed a screen of phage cDNA expression libraries to identify novel substrates of the protein tyrosine kinase Src. One of these, Tks5 (previously known as Fish), is a large scaffolding protein with an amino-terminal PX domain and five SH3 domains. In normal fibroblasts, Tks5 is cytoplasmic, but the protein is found in podosomes when the cells are transformed with Src. Usin...
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The osteoclast is distinguished from other macrophage polykaryons by its polarization, a feature induced by substrate recognition. The most striking component of the polarized osteoclast is its ruffled membrane, probably reflecting insertion of intracellular vesicles into the bone apposed plasmalemma. The failure of osteoclasts in c-src-/- osteopetrotic mice to form ruffled membranes indicates ...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2009
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2009.08.017